A strong direct association between the concomitant pathology of acne vulgaris and an increase in the number of initial forms of erythrocyte deformation (red blood cell shape changes) confirms the influence of functional gallbladder disorder on the morphological characteristics of red blood cells (how red blood cells look) and the occurrence of poikilocytosis (irregularly shaped red blood cells). An increase in the number of pathological forms of erythrocytes (abnormal red blood cells) under conditions of comorbidity (presence of multiple disorders) leads to disorders of microcirculation (small blood vessel circulation problems), the progression of inflammation, the persistence of microbiota (microorganisms) and Demodex (skin mites), which significantly declines the prognosis of the disease (worsens the outlook).
https://wiadlek.pl/wp-content/uploads/archive/2020/WLek202002115.pdf
The results suggest prevalence of acne vulgaris among student cohort aged 19 to 29 is 80 % with
predominantly mild degree of severity. Comorbidity of acne vulgaris with Demodex mites occurs in 70 % of the
cases. Combination of acne vulgaris with functional gallbladder disorder was found in 44 % of the cases; with
the increasing of frequency of gallbladder dysfunction up to 54 % in moderate acne vulgaris
https://www.rjpbcs.com/pdf/2019_10(4)/[7].pdf(edited)
Here are some compounds that may help with bile composition / gallstone prevention:
Ursodeoxycholic acid (UDCA): While not strictly a dietary compound, this naturally occurring bile acid has been used medically to dissolve certain types of gallstones.
TUDCA
Choline
Lecithin: This mixture of phospholipids, primarily composed of phosphatidylcholine, has shown promise in reducing cholesterol saturation in bile and potentially preventing gallstone formation.
Milk Thistle
Plant sterols: These compounds may help reduce cholesterol absorption and bile saturation, potentially preventing gallstone formation.
Omega-3 fatty acids: These have shown potential in reducing cholesterol saturation in bile and preventing gallstone formation in some animal studies.
Vitamin C: Studies have suggested that vitamin C can help break down cholesterol gallstones in animal models.
Caffeine: Some studies have suggested that regular coffee consumption may reduce the risk of gallstone formation in humans.
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